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KMID : 0381219880200040416
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Journal of RIMSK
1988 Volume.20 No. 4 p.416 ~ p.421
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An Experimental Study of Granular from of Dense Hydroxyapatite as a Bone Substitute
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Abstract
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The aim of replacing osseous structure is preservation of morphologic contour, restoration of mechanical strength and function, elimination of dead space to reduce postoperative infection and thus promote healing.
The extensive studies on the replacement of osseous tissue recommended the use of bone substitutes for filling defects caused by various reasons, and many investigators had experienced with variety of materials such as calcium salts and calcium phosphate ceramics.
These implant materials should have several prerequisite which include a lack of local or systemic toxicity, a lack of inflammatory of foreign body response, an absence of intervening fibrous tissue between implant and bone, and apparent ability to become directly bonded to bone.
Until now a dense hydroxyapatite, a form of calcium phosphate ceramic, is neglected for bone substitute because these materials is very hard and very low bioresorption rate and does not present some of the possible concerns about bone in growth.
A granular form of dense hydroxyapatited in this study provides pore and interconnecting macropore similar to porous hydroxyapatite theoretically and so space for bone in growth.
In this study a form of dense hydroxyapatite was implanted in the posterior portion of the right iliac crest of 14 dogs and two dogs each time were sacrificed at 2, 4, 6, 8, 12, 16, and 20 weeks after implantation.
The scanning electron micrograph showed progressively tight adherence of the implant to the adjacent bony structure without intervening fibrous tissue and suggested that a granular form of dense hydroxyapatite is suitable as a bone substitute for filling osseous defect.
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